2/14/2023 0 Comments Mims drug handbook equipment![]() As the peak effect for warfarin takes at least 4-5 days, in the initial stage of VTE, concurrent administration of daily subcutaneous injections of low molecular weight heparin (LMWH) is needed until INR reaches therapeutic levels. As it has a narrow therapeutic index, VKAs require frequent coagulation monitoring with International Normalised Ratio (INR) to adjust and optimize the dose for each individual. For more than 50 years since the 1940s, vitamin K antagonists (VKAs) such as warfarin were the mainstay of oral anticoagulation therapy for VTE. Most patients with VTE receive anticoagulation therapy for 3 months or longer. Left untreated, it could result in significant morbidity and mortality. It comprises deep vein thrombosis and pulmonary embolism. Venous thromboembolism (VTE) is a serious medical condition. Practical considerations in the choice of pharmacological therapy (VKAs vs NOACs) for venous thromboembolism
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